Research benefits for hypothetical HIV vaccine trials: The views of Ugandans in the Rakai District.
نویسندگان
چکیده
Opinion Leaders (OL) 150 opinion leaders identified through SOLnet and 50 randomly chosen community mobilizers. Males and females. Not receiving study compensation. Community opinion leaders in three Rakai District community clusters who were identified through a separate sociometric survey (SOLnet study) and/or selected based on their local council leadership status. a. Formerly Community HIV Epidemiology Research (CHER). Molecular Epidemiology Research (MER) 125 males randomly selected from >600 seroconverters. Research participants in a substudy to characterize HIVsubtypes and viral set points among recent HIV seroconverters identified through the RCCS.
منابع مشابه
Monitoring and Evaluation of National HIV Prevention, AIDS Care and STD Control Programs (Uganda case study)
The first documented cases of AIDS in Uganda were reported in October 1985. Early cases, however, were seen in 1982, in the Rakai district (Southwestern Uganda). Since then the AIDS epidemic has spread to all parts of Uganda. In 1988, a national serosurvey was conducted under WHO to establish the extent of HIV infection in Uganda. This survey revealed that about one million Ugandans were HIV po...
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The impact of HIV-1 genetic diversity on candidate vaccines is uncertain. To minimize genetic diversity in the evaluation of HIV-1 vaccines, vaccine products must be matched to the predominant subtype in a vaccine cohort. To that end, full genome sequencing was used to detect and characterize HIV-1 subtypes and recombinant strains from individuals in Rakai District, Uganda. DNA extracted from p...
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OBJECTIVE To determine the association between the incidence of HIV-1 infection and the genetic complexity of HIV-1 strains in 2 geographic strata within Rakai District, Uganda. METHODS Study volunteers with recent HIV-1 infections during the period 1997 through 2003 were recruited from 10 communities that were geographically stratified as a main road trading center (n = 5) or a secondary roa...
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To explore how to better educate rural Africans about preventive HIV/AIDS vaccine trials, 15 semi-structured, open-ended interviews were conducted with villagers in Lyantonde, Rakai District, Uganda. This study reports on the findings by focusing on the attitudes, knowledge and questions the rural villagers had about HIV/AIDS-preventive vaccine testing. While several interviewees confused preve...
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عنوان ژورنال:
- IRB
دوره 30 2 شماره
صفحات -
تاریخ انتشار 2008